Author

M. Pinilla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. Meunier· 5 shared A. Hessel· 4 shared K. Santoni· 4 shared R. Planes· 4 shared C. Cougoule· 3 shared S. Bagayoko· 3 shared d. pericat· 2 shared E. Eren· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersImmunology

E. Meunier

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells

F. L. Zhong, P. Rozario, M. Pinilla, A. C. Vind, K. Robinson, T. Gee Ann, M. Jasrie Firdaus, J. Francisco Martinez, L. Zhewang, S. Bekker-Jensen, E. Meunier

This study identifies the mechanism by which nigericin activates the NLRP1 inflammasome in human epithelial cells through potassium efflux and ribotoxic stress response.

bioRxiv · Jun 23, 2023 · PreprintImmunology

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection

M. Pinilla, R. Mazars, R. Verge, L. Gorse, K. Santoni, K. S. Robinson, G. A. Toh, L. Prouvensier, S. A. Leonicaza, A. Hessel, d. pericat, M. Murris, A. Henras, J. M. Buyck, C. Cougoule, , E. Meunier

This paper shows that Pseudomonas aeruginosa's Exotoxin A activates the NLRP1 inflammasome via EEF2 inactivation, causing epithelial damage and pyroptosis, and identifies ZAK as a key sensor in this process.

bioRxiv · Jan 16, 2023 · PreprintImmunology

Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection

K. Santoni, D. Pericat, M. Pinilla, S. Bagayoko, A. Hessel, S. A. Leon-Ycaza, E. Bellard, S. Mazeres, E. Doz-Deblauwe, N. Winter, C. Paget, J.-P. Girard, C. Cougoule, R. Poincloux, M. Lamkanfi, , R. Planes

This study shows that Pseudomonas aeruginosa induces Caspase-1-dependent pyroptosis in neutrophils, leading to incomplete NETosis and promoting bacterial spread.

bioRxiv · Jun 28, 2021 · PreprintImmunology

Phospholipid peroxidation fuels ExoU phospholipase-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

S. Bagayoko, S.-A. Leon-Icaza, M. Pinilla, A. Hessel, K. Santoni, P.-J. Bordignon, F. Moreau, E. Eren, A. Boyance, E. Naser, L. Lefevre, C. Berrone, N. Iacobachvili, A. Metais, Y. Rombouts, , E. Meunier

This study identifies phospholipid peroxidation as a mechanism enhancing ExoU phospholipase activity, leading to cell necrosis and supporting Pseudomonas aeruginosa pathogenesis.

bioRxiv · Feb 17, 2021Immunology

Irgm2 and Gate-16 cooperatively dampen targeting of caspase-11 to Gram-negative bacterial products

E. Eren, R. Planes, S. Bagayoko, P.-J. Bordignon, K. Chaoui, A. Hessel, K. Santoni, M. Pinilla, O. Schiltz, J. C. Howard, M. Yamamoto, E. Meunier

This study identifies Irgm2 and Gate-16 as cooperative regulators that dampen non-canonical inflammasome activation by reducing caspase-11 targeting to intracellular bacteria.

bioRxiv · Mar 6, 2020Immunology