Author

S. A. Lewis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Research Focus:differential expression· 5 Approach:experimental assay· 5 Assay:scRNA-seq· 5 Approach:statistical model· 5 Research Focus:gene regulatory network inference· 4 Organism:rat· 3 Organism:human· 2

Frequent Co-Authors

I. Messaoudi· 6 shared K. A. Grant· 4 shared B. Doratt· 3 shared S. Sureshchandra· 3 shared A. Jankeel· 2 shared B. M. Doratt· 2 shared I. R. Cinco· 2 shared M. B. Blanton· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersImmunology

I. Messaoudi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung

S. A. Lewis, I. R. Cinco, B. M. Doratt, M. B. Blanton, C. Hoagland, M. Davies, K. A. Grant, I. Messaoudi

This study shows chronic alcohol consumption reduces antiviral cytokine induction and disrupts TLR signaling in lung cells from humans and rhesus macaques infected with SARS-CoV-2.

bioRxiv · May 2, 2023Immunology

Integrated single cell analysis shows chronic alcohol drinking disrupts monocyte differentiation in the bone marrow niche

S. A. Lewis, B. M. Doratt, Q. Qiao, M. B. Blanton, K. A. Grant, I. Messaoudi

This study shows chronic alcohol consumption disrupts monocyte differentiation in the bone marrow niche, leading to heightened inflammation and compromised anti-microbial defenses in circulating monocytes.

bioRxiv · Mar 29, 2023Immunology

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death

J. Moral-Sanz, S. A. Lewis, S. MacMillan, M. Meloni, H. McClafferty, B. Viollet, M. Foretz, J. del-Pozo, A. M. Evans

This study shows that AMPK-1/2 deficiency in smooth muscles leads to persistent pulmonary hypertension and premature death in mice, with no systemic vasculopathy.

bioRxiv · Jun 8, 2022 · PreprintPathology

Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging: insights from rhesus macaques

N. S. Rhoades, M. Davies, S. A. Lewis, I. R. Cinco, S. G. Kohama, L. E. Bermudez, K. L. Winthorp, C. Fuss, J. A. Mattison, E. R. Spindel, I. Messaoudi

This study examines age-related changes in lung function, immunity, and microbiota in rhesus macaques, revealing shifts in immune cell populations and microbial composition associated with healthy aging.

bioRxiv · Feb 8, 2022 · PreprintImmunology

Chronic ethanol drinking in non-human primates induces inflammatory cathepsin gene expression in alveolar macrophages accompanied by functional defects

S. A. Lewis, B. Doratt, S. Sureshchandra, A. Jankeel, N. Newman, K. A. Grant, I. Messaoudi

This study shows chronic ethanol drinking in rhesus macaques increases inflammatory gene expression and functional defects in alveolar macrophages, linking to increased infection susceptibility.

bioRxiv · Jul 30, 2021 · PreprintImmunology

Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine

S. Sureshchandra, S. A. Lewis, B. Doratt, A. Jankeel, I. Ibraim, I. Messaoudi

This study compares the adaptive immune response to SARS-CoV-2 mRNA vaccine and natural infection, finding robust CD4 T and B cell responses but weak and variable CD8 T cell responses.

bioRxiv · Jul 14, 2021Immunology

Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinking

S. A. Lewis, S. Sureshchandra, B. Doratt, V. Jimenez, C. Stull, K. A. Grant, I. Messaoudi

This study examines how chronic alcohol drinking affects monocytes and macrophages in non-human primates, revealing hyper-inflammatory responses and impaired function.

bioRxiv · May 12, 2021Immunology