Author

F. M. Ferguson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

N. S. Gray· 3 shared A. Boussioutas· 1 shared A. I. Azimpour· 1 shared A. J. Tao· 1 shared A. L. Chand· 1 shared A. L. E. Carli· 1 shared A. L. Leggett· 1 shared A. Robichaud· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

N. S. Gray

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Author profile →

4 papers

Recent·Most cited

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ

A. J. Tao, J. Jiang, G. E. Gadbois, P. Goyal, B. T. Boyle, E. J. Mumby, S. A. Myers, J. G. English, F. M. Ferguson

The paper introduces the BioTAC system to map small molecule interactomes in situ, enabling the identification of both direct and complexed binding proteins with high confidence.

bioRxiv · Aug 21, 2023 · PreprintPharmacology & Toxicology

The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscape

S. Afshar-Sterle, A. L. E. Carli, R. O'Keefe, J. Tse, S. Fischer, A. I. Azimpour, D. Baloyan, L. Elias, P. Thilakasiri, O. Patel, F. M. Ferguson, M. F. Eissmann, A. L. Chand, N. S. Gray, R. Busuttil, , M. Buchert

This study identifies DCLK1 kinase activity as a driver of gastric cancer progression by reprogramming the tumor stroma and promoting invasiveness and metastasis.

bioRxiv · Apr 21, 2022 · PreprintCancer Biology

Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

B. Nabet, F. M. Ferguson, B. K. A. Seong, M. Kuljanin, A. L. Leggett, M. L. Mohardt, A. Robichaud, A. S. Conway, D. L. Buckley, J. D. Mancias, J. E. Bradner, K. Stegmaier, N. S. Gray

This paper introduces dTAGV-1, a VHL-recruiting dTAG molecule that rapidly degrades FKBP12F36V-tagged proteins, overcoming limitations of CRBN-recruiting dTAGs and enabling combination degrader studies in cells and mice.

bioRxiv · Mar 13, 2020Cancer Biology

Targeting the PI5P4K lipid kinase family in cancer using novel covalent inhibitors

S. C. Sivakumaren, H. Shim, T. Zhang, F. M. Ferguson, M. R. Lundquist, C. M. Browne, H.-S. Seo, M. N. Paddock, T. D. Manz, B. Jiang, M.-F. Hao, P. Krishnan, D. G. Wang, T. J. Yang, N. P. Kwiatkowski, , N. S. Gray

This study identifies THZ-P1-2, a covalent pan-PI5P4K inhibitor, showing efficacy in AML/ALL cell lines and autophagy disruption, supporting PI5P4Ks as therapeutic targets in cancer.

bioRxiv · Oct 25, 2019Cancer Biology