Inhibition of mitochondrial dynamics preferentially targets pancreatic cancer cells with enhanced tumorigenic and invasive potential
S. Courtois, B. de Luxan-Delgado, L. Penin-Peyta, A. Royo-Garcia, B. Parejo-Alonso, P. Jagust, S. Alcala, J. A. Rubiolo, L. Sanchez, B. Sainz, C. Heeschen, P. Sancho
This study shows that inhibiting mitochondrial fission with mDivi-1 selectively kills pancreatic cancer stem cells by causing mitochondrial dysfunction and energy crisis.
bioRxiv · Jan 17, 2021Cancer Biology