L. Sanchez

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds

This study uses CRISPR to eliminate the FOXL2 c.402C>G mutation in granulosa tumor cells, reducing malignancy and identifying anti-tumoral compounds.

Microbial metabolomics' latest SICRIT: Soft ionization by Chemical Reaction in-Transfer mass spectrometry

This study compares SICRIT and ESI ionization methods in microbial metabolomics, finding SICRIT ionizes different metabolites and more efficiently ionizes lipids in positive mode.

Unlocking genome-based prediction and selection in conifers: the key role of within-family prediction accuracy

The paper compares genome-based (GBLUP) and pedigree-based (ABLUP) prediction methods in maritime pine, finding that GBLUP's within-family accuracy is low but can be improved with sufficient training data.

A label-free approach for relative spatial quantitation of c-di-GMP in microbial biofilms

This study develops a label-free method to detect spatial changes in c-di-GMP levels in microbial biofilms using MALDI-MSI and applies it to three bacterial species.

Shigella generates distinct IAM subpopulations during epithelial cell invasion to promote efficient intracellular niche formation

This study identifies distinct IAM subpopulations during Shigella invasion that facilitate BCV disassembly through SNX8 and RAB11A recruitment.

Modelling metastasis in zebrafish unveils regulatory interactions of cancer-associated fibroblasts with circulating tumour cells

This study uses zebrafish to model interactions between circulating tumour cells and cancer-associated fibroblasts, showing that physical clustering enhances CTC survival and proliferation through paracrine signaling.

Gasdermin B over-expression arbitrates HER2-targeted therapy resistance by inducing protective autophagy

This study identifies GSDMB over-expression as a driver of HER2-targeted therapy resistance through autophagy induction and shows that combining lapatinib with chloroquine enhances therapeutic efficacy in GSDMB-positive tumors.

Pneumococcus uses COMMD2 to alter host cellular immunity.

This study identifies COMMD2 as a bacterial factor that interacts with p65 and p62 to degrade p65, altering host cellular immunity during pneumococcal infection.

High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern

This study demonstrates that therapeutic equine polyclonal antibodies effectively neutralize SARS-CoV-2 variants of concern.

Targeting the mitochondrial RNA methyltransferase TRMT61B reveals new therapeutic opportunities in aneuploid cancer cells

This study identifies TRMT61B as a therapeutic target in aneuploid cancer cells by showing its role in mitochondrial function and tumor progression.

Bioptim, a Python framework for Musculoskeletal Optimal Control in Biomechanics

Bioptim is a Python framework for musculoskeletal optimal control in biomechanics, providing efficient and customizable solutions for various biomechanical problems.

How to achieve a higher selection plateau in forest tree breeding? Fostering Heterozygote x Homozygote relationships in Optimal Contribution Selection in the case study of Populus nigra

The paper introduces a new genomic relationship matrix formulation for Genomic Optimal Contribution Selection (GOCS) to improve genetic gain and diversity in Populus nigra breeding.

Inhibition of mitochondrial dynamics preferentially targets pancreatic cancer cells with enhanced tumorigenic and invasive potential

This study shows that inhibiting mitochondrial fission with mDivi-1 selectively kills pancreatic cancer stem cells by causing mitochondrial dysfunction and energy crisis.

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

This paper develops and pre-clinically evaluates two equine-derived anti-SARS-CoV-2 polyclonal formulations for potential COVID-19 treatment, showing high neutralizing capacity against SARS-CoV-2 infection.

Sequential development of embryoblast-like memory entities in human cancer tissues: An evolutionary self-repair structure with pluripotentiality

The paper identifies embryoblast-like memory entities in human cancer tissues that exhibit pluripotentiality and self-repair capabilities, suggesting potential for regenerative medicine and targeted therapies.

Discovery of a microbially produced small molecule in a host-specific organ

The paper identifies a diketopiperazine small molecule produced by Vibrio fischeri that modulates luminescence and is detected in the squid's light organ, linking biofilm formation and symbiosis maintenance.

Rapid evolution of coordinated and collective movement in response to artificial selection

This study shows that artificial selection on guppies rapidly increases social coordination and collective movement traits.