Single-cell landscapes of primary glioblastomas and matched organoids and cell lines reveal variable retention of inter- and intra-tumor heterogeneity
V. G. LeBlanc, D. L. Trinh, S. Aslanpour, M. Hughes, D. Livingstone, M. D. Blough, J. G. Cairncross, J. A. Chan, J. J. Kelly, M. A. Marra
The paper analyzes genetic and transcriptional profiles of glioblastomas, organoids, and cell lines to show variable retention of tumor heterogeneity in organoids and uniformity in cell lines.
bioRxiv · Apr 24, 2021Cancer Biology