M. A. Marra

Multi-omic analysis of CIC's functional networks reveals novel interaction partners and a potential role in mitotic fidelity

This study uses multi-omic approaches to analyze CIC's functional networks, identifying novel interactions and revealing its role in mitotic fidelity and transcriptional splicing.

Robust somatic copy number estimation using coarse-to-fine segmentation

Ploidetect improves CNV detection in tumors with higher sensitivity and accuracy, enabling analysis of chromosomal instability in a multi-cancer cohort.

Single-cell landscapes of primary glioblastomas and matched organoids and cell lines reveal variable retention of inter- and intra-tumor heterogeneity

The paper analyzes genetic and transcriptional profiles of glioblastomas, organoids, and cell lines to show variable retention of tumor heterogeneity in organoids and uniformity in cell lines.

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

Comprehensive characterization of pediatric AML reveals diverse fusion oncoproteins and age-specific mutational interactions

This study characterizes the molecular landscape of pediatric AML, identifying age-specific mutations and fusion oncoproteins that differ from adult AML.