Author

T. B. Blum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. P. Abrahams· 2 shared A. Burrell· 1 shared A. Odriozola· 1 shared A. Vaithia· 1 shared B. Drepper· 1 shared B. Khanppnavar· 1 shared B. Zuber· 1 shared D. Poppleton· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

J. P. Abrahams

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis of connexin-36 gap junction channel inhibition

X. Ding, S. Aureli, A. Vaithia, P. Lavriha, D. Schuster, B. Khanppnavar, X. Li, T. B. Blum, P. Picotti, F. L. Gervasio, V. M. Korkhov

The paper reports the cryo-EM structure of connexin-36 bound to mefloquine, revealing how small molecules inhibit gap junction channels by partially occluding the pore and altering electrostatics.

bioRxiv · Dec 9, 2023Biophysics

A lipocalin mediates unidirectional haem biomineralization in malaria parasites

J. M. Matz, B. Drepper, T. B. Blum, E. van Genderen, A. Burrell, P. Martin, T. Stach, L. Collinson, J. P. Abrahams, K. Matuschewski, M. J. Blackman

This study identifies PV5, a lipocalin-like protein, as critical for controlling haem crystallization into haemozoin in malaria parasites, with implications for drug development.

Proceedings of the National Academy of Sciences · Jun 29, 2020Peer-reviewedMicrobiology

Cryptosporulation in Kurthia spp. forces a rethinking of asporogenesis in Firmicutes

S. Filippidou, M. Fatton, T. Junier, M. Berge, D. Poppleton, T. B. Blum, M. Kaminek, A. Odriozola, J. Blom, S. L. Johnson, J. P. Abrahams, P. S. G. Chain, S. Gribaldo, E. I. Tocheva, B. Zuber, , P. Junier

The paper demonstrates endosporulation in the genus Kurthia, previously considered asporogenic, and proposes a revised understanding of sporulation in Firmicutes.

bioRxiv · Jun 18, 2020 · PreprintMicrobiology