Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis
K. Togami, S. S. Chung, V. Madan, L. Cabal-Hierro, J. Taylor, S. S. Kim, G. K. Griffin, M. Ghandi, J. Li, Y. Y. Li, F. Angelot-Delettre, S. Biichle, M. Seiler, S. Buonamici, S. B. Lovitch, , A. A. Lane
The paper identifies sex-biased ZRSR2 mutations in BPDCN that impair pDC activation and apoptosis, linking X chromosome mutations to male-predominant leukemia.
bioRxiv · Oct 29, 2020Cancer Biology