Author

M. Seiler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Taylor· 2 shared O. Abdel-Wahab· 2 shared S. Buonamici· 2 shared A. A. Lane· 1 shared A. Louissaint· 1 shared A. Niedner· 1 shared B. J. E. Martin· 1 shared D. M. Weinstock· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

J. Taylor

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A consensus motif in ASH1 and further transcripts unifies several RNA motifs required for interaction with the She2p/She3p transport machinery and mRNA localization in yeast

M. Seiler, A. Niedner, S. Heber, M. Feldbruegge, R.-P. Jansen, D. Niessing, K. Zarnack

The paper identifies a consensus motif for She2p/3p recognition sites in yeast RNA, showing that spatial arrangement of sequence features is more important than sequence order for function.

bioRxiv · Mar 10, 2024 · PreprintCell Biology

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS/AML

E. C. Wheeler, B. J. E. Martin, W. C. Doyle, R. A. Gorelov, M. Donahue, J. C. Jann, O. Abdel-Wahab, J. Taylor, M. Seiler, S. Buonamici, R. Belizaire, K. Adelman, Z. Tothova

The paper shows SF3B1 splicing modulators impair DNA damage response in cohesin-mutant MDS/AML, leading to increased sensitivity to PARP inhibitors and chemotherapy.

bioRxiv · Sep 26, 2022Cancer Biology

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis

K. Togami, S. S. Chung, V. Madan, L. Cabal-Hierro, J. Taylor, S. S. Kim, G. K. Griffin, M. Ghandi, J. Li, Y. Y. Li, F. Angelot-Delettre, S. Biichle, M. Seiler, S. Buonamici, S. B. Lovitch, , A. A. Lane

The paper identifies sex-biased ZRSR2 mutations in BPDCN that impair pDC activation and apoptosis, linking X chromosome mutations to male-predominant leukemia.

bioRxiv · Oct 29, 2020Cancer Biology