Author

A. A. Lane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. M. Weinstock· 2 shared G. K. Griffin· 2 shared P. van Galen· 2 shared A. B. Miller· 1 shared A. K. Shalek· 1 shared A. Langenbucher· 1 shared A. Louissaint· 1 shared C. A. G. Booth· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

D. M. Weinstock

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targetable leukemia dependency on noncanonical PI3Kγ signaling

Q. Luo, E. G. Raulston, M. A. Prado, X. Wu, K. Gritsman, C. A. G. Booth, R. Xu, P. van Galen, J. G. Doench, S. Shimony, H. W. Long, D. S. Neuberg, J. A. Paulo, A. A. Lane

This study identifies a targetable dependency on noncanonical PI3Kγ signaling in acute leukemias, showing that PI3Kγ inhibition with eganelisib improves survival when combined with cytarabine.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

Leukemia circulation kinetics revealed through blood exchange method

A. B. Miller, A. Langenbucher, F. H. Rodriguez, L. Lin, C. Bray, S. Duquette, Y. Zhang, D. Goulet, A. A. Lane, D. M. Weinstock, M. T. Hemann, S. R. Manalis

This study uses a blood exchange method in mouse leukemia models to show that leukemia cells circulate longer than solid tumor cells and that microenvironmental factors like E-selectin influence their clearance.

bioRxiv · Sep 3, 2023Cancer Biology

Single-cell Multiomics Reveals Clonal T-cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm

E. A. DePasquale, D. Ssozi, M. Ainciburu, J. Good, J. Noel, M. Villanueva, C. Couturier, A. K. Shalek, S. F. Aranki, H. R. Mallidi, G. K. Griffin, A. A. Lane, P. van Galen

This study uses single-cell multiomics to analyze T-cell responses in BPDCN, finding upregulated IFNA and downregulated TNFA pathways, along with T-cell exhaustion and clonotype expansion.

bioRxiv · Dec 1, 2021Immunology

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis

K. Togami, S. S. Chung, V. Madan, L. Cabal-Hierro, J. Taylor, S. S. Kim, G. K. Griffin, M. Ghandi, J. Li, Y. Y. Li, F. Angelot-Delettre, S. Biichle, M. Seiler, S. Buonamici, S. B. Lovitch, , A. A. Lane

The paper identifies sex-biased ZRSR2 mutations in BPDCN that impair pDC activation and apoptosis, linking X chromosome mutations to male-predominant leukemia.

bioRxiv · Oct 29, 2020Cancer Biology