Disruption of the surfactant protein A receptor SP-R210L (CD245α/MYO18Aα) alters respiratory function and iron sequestration in alveolar macrophages of aged mice
E. Yau, T. M. Umstead, R. Abdulqadir, K. Fino, Z. Guan, S. Hu, S. Diangelo, K. Hassan, S. Bingaman, H. M. Atkins, T. K. Cooper, A. C. Arnold, E. S. Halstead, Z. C. Chroneos
This study shows that disrupting the SP-R210L isoform in aged mice impairs respiratory function and iron sequestration in alveolar macrophages, leading to chronic dysregulation and increased interstitial lung disease risk.
bioRxiv · Apr 14, 2021 · PreprintPhysiology