Author

T. M. Umstead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. Yau· 2 shared Z. C. Chroneos· 2 shared A. C. Arnold· 1 shared C. Song· 1 shared E. S. Halstead· 1 shared H. M. Atkins· 1 shared J. Web· 1 shared K. Fino· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

E. Yau

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Author profile →

2 papers

Recent·Most cited

Disruption of the surfactant protein A receptor SP-R210L (CD245α/MYO18Aα) alters respiratory function and iron sequestration in alveolar macrophages of aged mice

E. Yau, T. M. Umstead, R. Abdulqadir, K. Fino, Z. Guan, S. Hu, S. Diangelo, K. Hassan, S. Bingaman, H. M. Atkins, T. K. Cooper, A. C. Arnold, E. S. Halstead, Z. C. Chroneos

This study shows that disrupting the SP-R210L isoform in aged mice impairs respiratory function and iron sequestration in alveolar macrophages, leading to chronic dysregulation and increased interstitial lung disease risk.

bioRxiv · Apr 14, 2021 · PreprintPhysiology

Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages

E. Yau, Y. Chen, C. Song, J. Web, M. Carillo, Y. I. Kawasawa, Z. Tang, Y. Takahashi, T. M. Umstead, S. Dovat, Z. C. Chroneos

This study investigates how the absence of the SP-R210L isoform in macrophages leads to a hyper-inflammatory state through altered genomic and epigenomic responses.

bioRxiv · Apr 2, 2021Immunology