Author

S. C. Keane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Kotar· 3 shared S. Ma· 3 shared Y. Liu· 2 shared A. Lohmeier· 1 shared A. Munsayac· 1 shared B. A. Bitterman· 1 shared B. A. Johnson· 1 shared B. L. Johnson· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiophysics

A. Kotar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Use of steric blocking antisense oligonucleotides for the targeted inhibition of junction containing precursor microRNAs

S. Ma, S. A. Howden, S. C. Keane

This study demonstrates that steric blocking antisense oligonucleotides can inhibit pre-miRNA processing by targeting structural junctions, validating their use in modulating miRNA production.

bioRxiv · Apr 8, 2024 · PreprintBiochemistry

Structure of pre-miR-31 reveals an active role in Dicer processing

S. Ma, A. Kotar, S. Grote, S. Rouskin, S. C. Keane

The paper determines the structure of pre-miR-31 and identifies structural elements that influence Dicer processing.

bioRxiv · Jan 3, 2023 · PreprintBiophysics

Solution structure of NPSL2, a regulatory element in the oncomiR-1 RNA

Y. Liu, A. Munsayac, I. Hall, S. C. Keane

The paper determines the solution structure of NPSL2, an RNA element regulating miR-17~92a processing, revealing its hairpin structure and pH-sensitive features.

bioRxiv · Mar 27, 2022Biophysics

pH dependence of C·A, G·A and A·A mismatches in the stem of precursor microRNA-31

A. Kotar, S. Ma, S. C. Keane

The paper investigates the structural properties of three base pair mismatches in pre-miRNA-31 using NMR and thermal denaturation, revealing their pH-dependent behavior.

bioRxiv · Oct 25, 2021Biophysics

NMR chemical shift assignments of RNA oligonucleotides to expand the RNA chemical shift database

Y. Liu, A. Kotar, T. L. Hodges, K. Abdallah, M. H. Taleb, B. A. Bitterman, S. Jaime, K. J. Schaubroeck, E. Mathew, N. W. Morgenstern, A. Lohmeier, J. L. Page, M. Ratanapanichkich, G. Arhin, B. L. Johnson, , S. C. Keane

The paper reports chemical shift assignments for 12 RNA hairpins to enhance the BMRB database.

bioRxiv · May 20, 2021Biophysics