S. Chocarro

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

This study shows that Plk1-induced chronic chromosome instability in breast cancer leads to immune suppression through RELB signaling and PD-L1 upregulation.

Diverse routes of Club cell evolution in lung adenocarcinoma

This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.