B. Brors

Direct excitatory synapses between neurons and tumor cells drive brain metastatic seeding of breast cancer and melanoma

The paper shows neurons form direct excitatory synapses with brain-metastatic breast and melanoma cancer cells, supporting metastasis and offering new therapeutic targets.

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

This study identifies epigenetic changes in AT2 cells from COPD patients that disrupt IFN and WNT pathways, impairing lung regeneration.

Multiple myeloma long-term survivors display sustained immune alterations decades after first line therapy

This study examines immune changes in multiple myeloma survivors years after treatment, finding sustained immune alterations linked to residual disease and therapy.

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

This study shows that Plk1-induced chronic chromosome instability in breast cancer leads to immune suppression through RELB signaling and PD-L1 upregulation.

High-resolution epigenetic profiling identifies novel regulators of COPD in human lung fibroblasts

This study identifies novel epigenetic and transcriptomic regulators of COPD in human lung fibroblasts across disease stages.

Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells.

The paper integrates single-cell chromatin accessibility and RNA-seq to analyze enhancer landscapes in human tumor-infiltrating T cells, identifying key regulatory elements and their role in TIL dysfunction.

Hematopoietic stem cells fail to regenerate following inflammatory challenge.

This study shows that repeated inflammatory challenges lead to progressive depletion of functional HSCs with no recovery, contributing to age-related hematopoietic decline.

Dissecting intratumor heterogeneity of nodal B cell lymphomas on the transcriptional, genetic, and drug response level

This study examines intratumor heterogeneity in B cell lymphomas by analyzing transcriptional, genetic, and drug response profiles across malignant subclones and immune cells.