High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methods
C. R. Merritt, G. T. Ong, S. Church, K. Barker, G. Geiss, M. Hoang, J. Jung, Y. Liang, J. McKay-Fleisch, K. Nguyen, K. Sorg, I. Sprague, C. Warren, S. Warren, Z. Zhou, , J. M. Beechem
This paper introduces Digital Spatial Profiling (DSP), a method for high-plex spatial analysis of proteins and RNA in tissue, and demonstrates its application in studying immune and cancer microenvironments.
bioRxiv · Feb 26, 2019 · PreprintPathology