ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages
T. A. Bates, M. Trank-Greene, X. Nguyenla, A. Anastas, S. Gurmessa, I. R. Merutka, S. D. Dixon, A. Shumate, A. R. Groncki, M. A. Parson, J. R. Ingram, E. Barklis, J. E. Burke, U. Shinde, H. L. Ploegh, F. G. Tafesse
This study investigates ESAT-6's self-association under acidic conditions and shows an ESAT-6-specific nanobody inhibits M. tuberculosis growth in macrophages.
bioRxiv · Aug 16, 2023Biochemistry