Author

X. Nguyenla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. Stanley· 5 shared E. Van Dis· 3 shared E. Wehri· 3 shared J. Schaletzky· 3 shared L. H. Yamashiro· 3 shared C. Dugast-Darzacq· 2 shared R. M. Jong· 2 shared S. B. Biering· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersImmunology

S. Stanley

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

T. A. Bates, M. Trank-Greene, X. Nguyenla, A. Anastas, S. Gurmessa, I. R. Merutka, S. D. Dixon, A. Shumate, A. R. Groncki, M. A. Parson, J. R. Ingram, E. Barklis, J. E. Burke, U. Shinde, H. L. Ploegh, F. G. Tafesse

This study investigates ESAT-6's self-association under acidic conditions and shows an ESAT-6-specific nanobody inhibits M. tuberculosis growth in macrophages.

bioRxiv · Aug 16, 2023Biochemistry

Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function

R. M. Jong, K. Ching, N. E. Garelis, A. Zilinskas, X. Nguyenla, S. Rawal, B. Hill, B. Luckie, L. Shallow, J. S. Cox, G. Barton, S. Stanley

This paper introduces a Cas9+ER-Hoxb8 neutrophil progenitor cell line for CRISPR screening to study neutrophil differentiation and function, identifying key genes like Cebpe and the WASH complex.

bioRxiv · Jul 19, 2022Immunology

An intranasal ASO therapeutic targeting SARS-CoV-2

C. Zhu, J. Y. Lee, J. Z. Woo, L. Xu, X. Nguyenla, L. H. Yamashiro, F. Ji, S. B. Biering, E. V. Dis, F. Gonzalez, D. Fox, A. Rustagi, B. A. Pinsky, C. A. Blish, C. Chiu, , A. M. Näär

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

bioRxiv · May 17, 2021Microbiology

Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2

S. B. Biering, E. Van Dis, E. Wehri, L. H. Yamashiro, X. Nguyenla, C. Dugast-Darzacq, T. G. Graham, J. R. Stroumza, G. R. Golovkine, A. W. Roberts, D. M. Fines, J. N. Spradlin, C. C. Ward, T. Bajaj, D. Dovala, , S. A. Stanley

This study screens FDA-approved compounds for antiviral activity against SARS-CoV-2 and identifies 13 effective compounds, including seven new candidates and one synergistic combination with remdesivir.

bioRxiv · Dec 30, 2020Microbiology

Mucosal vaccination with cyclic-di-nucleotide adjuvants induces effective T cell homing and IL-17 dependent protection against M. tuberculosis infection

R. M. Jong, E. Van Dis, X. Nguyenla, A. Baltodano, G. Pastenkos, C. Xu, N. Yosef, S. McWhirter, S. Stanley

This study shows mucosal vaccination with CDN adjuvants induces T cells that home to lungs and provide IL-17-dependent protection against M. tuberculosis.

bioRxiv · Nov 25, 2020 · PreprintImmunology

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

X. Nguyenla, E. Wehri, E. Van Dis, S. Biering, L. H. Yamashiro, J. Stroumza, C. Dugast-Darzacq, T. Graham, S. Stanley, J. Schaletzky

This study identifies 20 approved drugs that synergize with remdesivir to inhibit SARS-CoV-2 replication in human lung cells, with HCV NS5A inhibitors showing the strongest effects.

bioRxiv · Sep 18, 2020Microbiology

SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

A. Jack, L. S. Ferro, M. J. Trnka, E. Wehri, A. Nadgir, K. Costa, J. Schaletzky, A. Yildiz, X. Nguyenla, S. Stanley

This study shows that SARS-CoV-2 nucleocapsid protein forms condensates with viral RNA in vitro and in cells, driven by hydrophobic and electrostatic interactions.

bioRxiv · Sep 14, 2020Biophysics