Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice
J. D. Botezelli, P. Overby, L. Lindo, S. D. Wang, O. Haida, G. E. Lim, N. M. Templeman, J. R. Pauli, J. D. Johnson
This study shows that reducing insulin in mice increases oxidative mitochondrial proteins in inguinal white adipose tissue and upregulates Ucp1 in mesenteric WAT and BAT under high-fat diet conditions.
bioRxiv · Mar 31, 2020Physiology