Author

G. E. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Y. Mugabo· 2 shared A. Ghosh· 1 shared C. Zhao· 1 shared D. J. Hodson· 1 shared E. E. Mulvihill· 1 shared E. Fadzeyeva· 1 shared F. Abou Azar· 1 shared F. Pare· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Y. Mugabo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: Repurposing drugs to disrupt 14-3-3 protein-BAD interactions

S. He, L. Delgadillo Silva, G. A. Rutter, G. E. Lim

This paper uses a BRET-based high-throughput screen to identify FDA-approved drugs that disrupt 14-3-3{zeta}BAD interactions, showing potential for colorectal cancer treatment.

bioRxiv · Dec 14, 2023 · PreprintCancer Biology

Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signalling pathway

F. Abou Azar, Y. Mugabo, S. Yuen, S. Del Veliz, G. Lavoie, P. P. Roux, G. E. Lim

This study identifies plakoglobin as a novel regulator of adipogenesis, independent of the Wnt/β-catenin pathway, using the 14-3-3ζ interactome in mouse and human cells.

bioRxiv · Feb 3, 2022 · PreprintBiochemistry

14-3-3ζ constrains insulin secretion by regulating mitochondrial function in pancreatic β-cells

Y. Mugabo, C. Zhao, J. J. Tan, A. Ghosh, S. A. Campbell, E. Fadzeyeva, F. Pare, S. S. Pan, M. Galipeau, J. Ast, J. Broichhagen, D. J. Hodson, E. E. Mulvihill, S. Petropoulos, G. E. Lim

This study shows that 14-3-3ζ regulates insulin secretion in pancreatic β-cells by enhancing mitochondrial function and ATP synthesis, with implications for diabetes.

bioRxiv · Oct 17, 2021Physiology

Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice

J. D. Botezelli, P. Overby, L. Lindo, S. D. Wang, O. Haida, G. E. Lim, N. M. Templeman, J. R. Pauli, J. D. Johnson

This study shows that reducing insulin in mice increases oxidative mitochondrial proteins in inguinal white adipose tissue and upregulates Ucp1 in mesenteric WAT and BAT under high-fat diet conditions.

bioRxiv · Mar 31, 2020Physiology