Antinociceptive modulation by the adhesion-GPCR CIRL promotes mechanosensory signal discrimination
S. Dannhäuser, T. J. Lux, C. Hu, M. Selcho, J. Tsung-Chieh Chen, N. Ehmann, D. Sachidanandan, M. Pawlak, T. Langenhan, P. Soba, H. Rittner, R. J. Kittel
This study shows that CIRL modulates mechanosensory signals differently in low-threshold mechanoreceptors and high-threshold nociceptors, aiding in signal discrimination.
bioRxiv · Feb 24, 2020Physiology