A requirement for neutrophil glycosaminoglycans in chemokine:receptor interactions is revealed by the streptococcal protease SpyCEP
J. Goldblatt, R. A. Lawrenson, L. Muir, S. Dattani, T. Tsuchiya, S. Kanegasaki, S. Sriskandan, J. E. Pease
This study shows that SpyCEP cleavage of CXCL8 impairs chemokine-receptor interactions by disrupting glycosaminoglycan binding, affecting neutrophil migration.
bioRxiv · Dec 18, 2018Immunology