T. Tsuchiya

CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signalling

This study investigates CXCL17's structural and functional properties, finding it does not act as a chemokine but binds glycosaminoglycans and modulates chemotaxis.

Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction

This paper introduces a gut-liver-axis microphysiological system that applies physiologically relevant fluid shear stress to gut and liver cells, enhancing their survival and functional protein expression.

Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

The paper develops a gut-liver-on-a-chip platform to model NAFLD and shows co-culturing gut and liver cells alters gene expression and lipid accumulation in response to free fatty acids.

A requirement for neutrophil glycosaminoglycans in chemokine:receptor interactions is revealed by the streptococcal protease SpyCEP

This study shows that SpyCEP cleavage of CXCL8 impairs chemokine-receptor interactions by disrupting glycosaminoglycan binding, affecting neutrophil migration.