S. Sriskandan

Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response.

This study identifies the CpxRA cell envelope stress response as the driver of aminoglycoside heteroresistance in E. cloacae, showing its role in transient resistance and MIC elevation.

IS1-related large-scale deletion of chromosomal regions harbouring oxygen-insensitive nitroreductase gene nfsB causes nitrofurantoin heteroresistance in Escherichia coli

The paper identifies IS1-mediated chromosomal deletions in nfsB as a novel mechanism of nitrofurantoin heteroresistance in E. coli.

Characterization of the RofA regulon in the pandemic M1global and emergent M1UK lineages of Streptococcus pyogenes

This study characterizes the RofA regulon in two emm1 lineages of Streptococcus pyogenes, showing lineage-specific gene expression changes and potential regulatory impacts of SNPs in the PRD domain.

Multi-continental detection of Streptococcus pyogenes M1UK: Impact of ssrA SNP on SpeA expression in ancestral and M1UK isolates

This study investigates the impact of an ssrA SNP on SpeA expression in Streptococcus pyogenes isolates, showing its role in enhancing SpeA production but not being the sole determinant.

Characterisation of emergent toxigenic M1UK Streptococcus pyogenes and associated sublineages

This study characterizes the M1UK sublineage of Streptococcus pyogenes, identifying genetic and phenotypic differences that contribute to its dominance and increased virulence.

Ongoing emergence of M1UK lineage among invasive group A streptococcus isolates in 2020 and use of allele-specific PCR

The paper develops an allele-specific PCR to subtype emm1 Streptococcus pyogenes isolates, finding M1UK lineage dominates invasive infections in England in 2020.

Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

This study investigates SpyCEP's enzymatic function, revealing the C-terminal's role in substrate binding and the N-terminal's necessity for full catalytic activity.

Diverse Genetic Determinants of Nitrofurantoin Resistance in UK Escherichia coli

This study identifies genetic factors causing nitrofurantoin resistance in UK E. coli, finding mutations and insertion sequences in nfsA and nfsB as major contributors.

Vaccine-induced, but not natural immunity, against the Streptococcal Inhibitor of Complement protects against invasive disease

This study shows that vaccine-induced antibodies against SIC provide protection against invasive S. pyogenes infection, while natural antibodies do not.

The emergence of successful Streptococcus pyogenes lineages through convergent pathways of capsule loss and recombination directing high toxin expression

The paper identifies convergent evolutionary pathways in Streptococcus pyogenes lineages through recombination at the nga-slo locus and capsule loss, associated with increased toxin expression and disease success.

Diversity of Escherichia coli from the enteric microbiota in patients with Escherichia coli bacteraemia

This study compares the genetic diversity of E. coli in the gut microbiota of patients with E. coli bacteraemia versus other groups, finding reduced diversity in bacteraemia patients.

A requirement for neutrophil glycosaminoglycans in chemokine:receptor interactions is revealed by the streptococcal protease SpyCEP

This study shows that SpyCEP cleavage of CXCL8 impairs chemokine-receptor interactions by disrupting glycosaminoglycan binding, affecting neutrophil migration.

Streptococcal superantigen-induced expansion of human tonsil T cells leads to altered T follicular helper cell phenotype, B cell death, and reduced immunoglobulin release

This study shows that streptococcal superantigens alter T follicular helper cell phenotype, induce B cell death, and reduce immunoglobulin release in human tonsil cells.