S. G. Lin

Contribution of the IGCR1 regulatory element and the 3'Igh CBEs to Regulation of Igh V(D)J Recombination

This study investigates how IGCR1 regulatory elements and 3'Igh CBEs influence RAG-scanning and V(D)J recombination in progenitor-B cells through chromatin loop extrusion and WAPL down-regulation.

CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

This study shows that CTCF degradation promotes distal VH-to-DJH joining by enabling cohesin-driven RAG-scanning in pro-B cells.