Author

A. Y. Ye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

F. W. Alt· 5 shared H.-Q. Dai· 3 shared Y. Zhang· 3 shared Z. Ba· 3 shared A. C. Williams· 2 shared B. F. Haynes· 2 shared C. Jing· 2 shared H. Batra· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersImmunology

F. W. Alt

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Contribution of the IGCR1 regulatory element and the 3'Igh CBEs to Regulation of Igh V(D)J Recombination

Z. Liang, L. Zhao, A. Y. Ye, S. G. Lin, Y. Zhang, C. Guo, H.-Q. Dai, Z. Ba, F. W. Alt

This study investigates how IGCR1 regulatory elements and 3'Igh CBEs influence RAG-scanning and V(D)J recombination in progenitor-B cells through chromatin loop extrusion and WAPL down-regulation.

bioRxiv · Apr 21, 2023 · PreprintImmunology

Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors

S. Luo, C. Jing, A. Y. Ye, S. Kratochvil, C. A. Cottrell, J.-H. Koo, A. C. Williams, L. V. Francisco, H. Batra, E. Lamperti, O. Kalyuzhniy, Y. Zhang, A. Barbieri, J. P. Manis, B. F. Haynes, , F. W. Alt

This paper introduces new mouse models expressing human HIV-1 broadly neutralizing antibody (bnAb) precursors with more physiological levels and diversity, enhancing vaccine research for bnAb elicitation.

Proceedings of the National Academy of Sciences · Dec 27, 2022Peer-reviewedImmunology

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

S. Luo, J. Zhang, A. J. B. Kreutzberger, A. Eaton, R. J. Edwards, C. Jing, H.-Q. Dai, G. D. Sempowski, K. Cronin, R. Parks, A. Y. Ye, K. Mansouri, M. Barr, N. Pishesha, A. C. Williams, , F. W. Alt

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

bioRxiv · Jun 26, 2022 · PreprintImmunology

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination

H.-Q. Dai, H. Hu, J. Lou, A. Y. Ye, A. M. Chapdelaine-Williams, N. Kyritsis, Y. Zhang, N. Manfredonia, R. Judson, H. Chen, K. Johnson, S. Lin, Z. Ba, A. Conte, R. Casellas, , F. W. Alt

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

bioRxiv · Jun 30, 2020 · PreprintImmunology

CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

Z. Ba, J. Lou, E. W. Dring, A. Y. Ye, S. G. Lin, S. Jain, K.-R. Kieffer-Kwon, R. Casellas, F. W. Alt

This study shows that CTCF degradation promotes distal VH-to-DJH joining by enabling cohesin-driven RAG-scanning in pro-B cells.

bioRxiv · Jan 1, 2020Immunology