Author

H.-Q. Dai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Y. Ye· 3 shared F. W. Alt· 3 shared Y. Zhang· 2 shared Z. Ba· 2 shared A. C. Williams· 1 shared A. Conte· 1 shared A. Eaton· 1 shared A. J. B. Kreutzberger· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

A. Y. Ye

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Author profile →

3 papers

Recent·Most cited

Contribution of the IGCR1 regulatory element and the 3'Igh CBEs to Regulation of Igh V(D)J Recombination

Z. Liang, L. Zhao, A. Y. Ye, S. G. Lin, Y. Zhang, C. Guo, H.-Q. Dai, Z. Ba, F. W. Alt

This study investigates how IGCR1 regulatory elements and 3'Igh CBEs influence RAG-scanning and V(D)J recombination in progenitor-B cells through chromatin loop extrusion and WAPL down-regulation.

bioRxiv · Apr 21, 2023 · PreprintImmunology

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

S. Luo, J. Zhang, A. J. B. Kreutzberger, A. Eaton, R. J. Edwards, C. Jing, H.-Q. Dai, G. D. Sempowski, K. Cronin, R. Parks, A. Y. Ye, K. Mansouri, M. Barr, N. Pishesha, A. C. Williams, , F. W. Alt

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

bioRxiv · Jun 26, 2022 · PreprintImmunology

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination

H.-Q. Dai, H. Hu, J. Lou, A. Y. Ye, A. M. Chapdelaine-Williams, N. Kyritsis, Y. Zhang, N. Manfredonia, R. Judson, H. Chen, K. Johnson, S. Lin, Z. Ba, A. Conte, R. Casellas, , F. W. Alt

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

bioRxiv · Jun 30, 2020 · PreprintImmunology