Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection
C.-k. Oh, T. Nakamura, N. Beutler, X. Zhang, J. Pina-Crespo, M. Talantova, S. Ghatak, D. Trudler, L. N. Carnevale, S. R. McKercher, M. A. Bakowski, J. K. Diedrich, A. J. Roberts, A. K. Woods, V. Chi, , S. A. Lipton
This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.
bioRxiv · Apr 5, 2022Microbiology