Peptidyl tRNA hydrolase is required for robust prolyl-tRNA turnover in Mycobacterium tuberculosis
F. G. Tomasi, J. T. P. Schweber, S. Kimura, J. Zhu, L. A. T. Cleghorn, S. R. Green, S. H. Davis, M. K. Waldor, E. J. Rubin
The paper develops Cu-tRNAseq to study peptidyl tRNA turnover in Mtb, finding Pth is essential for prolyl-tRNA recycling and identifies Pth as a potential TB therapeutic target.
bioRxiv · Nov 15, 2022 · PreprintMicrobiology