Author

G. J. Baker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:batch correction / integration· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

P. K. Sorger· 4 shared S. Santagata· 3 shared J. L. Muhlich· 2 shared A. Claas· 1 shared A. Spektor· 1 shared B. Cheng· 1 shared C. Chidley· 1 shared C. D. Nicora· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersCancer Biology

P. K. Sorger

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4 papers

Recent·Most cited

2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer

S. Coy, B. Cheng, J. S. Lee, R. Rashid, L. Browning, Y. Xu, S. S. Chakrabarty, C. Yapp, S. Chan, J. B. Tefft, A. Spektor, K. L. Ligon, G. J. Baker, D. Pellman, P. K. Sorger, S. Santagata

The paper shows nuclear rupture is common in cancer, especially glioblastoma, and links it to lamin proteins and immune signaling.

bioRxiv · Nov 7, 2023 · PreprintCancer Biology

Quality Control for Single Cell Analysis of High-plex Tissue Profiles using CyLinter

G. J. Baker, E. Novikov, Z. Zhao, T. Vallius, J. A. Davis, J.-R. Lin, J. L. Muhlich, E. A. Mittendorf, S. Santagata, J. L. Guerriero, P. K. Sorger

This paper introduces CyLinter, a quality control tool that removes imaging artefacts from high-plex spatial profiling data, improving single-cell analysis of archival tumor specimens.

bioRxiv · Nov 1, 2023Pathology

Systemic immune response profiling with SYLARAS implicates a role for CD45R/B220+ CD8+ T cells in glioblastoma immunology

G. J. Baker, J. L. Muhlich, S. K. Palaniappan, J. K. Moore, S. H. Davis, S. Santagata, P. K. Sorger

The paper introduces SYLARAS, a tool for immune response profiling, and shows CD45R/B220+ CD8+ T cells are depleted in circulation and accumulate in glioblastoma tumors in mice, with similar cells found in human GBM.

bioRxiv · Oct 22, 2019 · PreprintImmunology

Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells

L. Gerosa, C. Chidley, F. Froehlich, G. Sanchez, S. K. Lim, J. Muhlich, J.-Y. Chen, G. J. Baker, D. Schapiro, T. Shi, L. Yi, C. D. Nicora, A. Claas, D. A. Lauffenburger, W.-J. Qian, , P. K. Sorger

The paper shows that sporadic ERK pulses in BRAFV600E melanoma cells drive non-genetic resistance to RAF/MEK inhibitors.

bioRxiv · Sep 8, 2019Cancer Biology