Author

F. G. Tomasi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. J. Rubin· 3 shared J. T. P. Schweber· 2 shared M. K. Waldor· 2 shared S. Kimura· 2 shared A. M. J. Hall· 1 shared C. L. Dulberger· 1 shared J. Zhu· 1 shared K. McGowen· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

E. J. Rubin

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3 papers

Recent·Most cited

A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth

F. G. Tomasi, S. Kimura, E. J. Rubin, M. K. Waldor

The paper identifies a tRNA modification in Mycobacterium tuberculosis that supports its intracellular growth by showing that its absence reduces bacterial growth in macrophages.

bioRxiv · Feb 20, 2023 · PreprintMicrobiology

Peptidyl tRNA hydrolase is required for robust prolyl-tRNA turnover in Mycobacterium tuberculosis

F. G. Tomasi, J. T. P. Schweber, S. Kimura, J. Zhu, L. A. T. Cleghorn, S. R. Green, S. H. Davis, M. K. Waldor, E. J. Rubin

The paper develops Cu-tRNAseq to study peptidyl tRNA turnover in Mtb, finding Pth is essential for prolyl-tRNA recycling and identifies Pth as a potential TB therapeutic target.

bioRxiv · Nov 15, 2022 · PreprintMicrobiology

A tRNA-acetylating toxin and detoxifying enzyme in Mycobacterium tuberculosis.

F. G. Tomasi, A. M. J. Hall, J. T. P. Schweber, C. L. Dulberger, K. McGowen, Q. Liu, S. M. Fortune, S. Helaine, E. J. Rubin

The paper identifies a TA system in Mtb, TacAT, where TacT acetylates tRNAs to inhibit translation and Pth reverses this effect, showing Pth's essentiality is unaffected by TacAT's absence.

bioRxiv · Dec 20, 2021Microbiology