S. Hemmi

A single oral immunization with a replication-competent adenovirus-vectored vaccine protects mice from influenza respiratory infection

This study shows that a single oral immunization with a replication-competent adenovirus-vectored vaccine protects mice from influenza, generating neutralizing antibodies and preventing viral replication.

The E3 ubiquitin ligase Mind bomb 1 enhances nuclear import of viral DNA by inactivating a virion linchpin protein that suppresses exposure of virion pathogen-associated molecular patterns

The paper shows that Mib1 ubiquitinates viral protein V to enable adenovirus DNA nuclear import, preventing innate immune activation.

The FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of human adenoviruses

This paper shows that the FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of certain human adenoviruses but not non-lytic transmission.