U. F. Greber

Spatiotemporal visualization of DNA replication by click chemistry reveals bubbling of viral DNA in virion formation

The paper uses click chemistry to visualize DNA replication in human adenovirus, showing distinct roles of early and late-replicated viral DNA in virion formation.

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

This study identifies alternative cell entry mechanisms for SARS-CoV-2 and other viruses, showing some rely on dynamin while others use actin-dependent pathways.

Methylene blue, Mycophenolic acid, Posaconazole, and Niclosamide inhibit SARS-CoV-2Omicron variant BA.1 infection of human airway epithelial explant cultures

The paper tests four drugs against SARS-CoV-2 Omicron BA.1 in human airway cultures, showing they inhibit infection and viral shedding.

Arrayed multicycle drug screens identify broadly acting chemical inhibitors for repurposing against SARS CoV 2

The paper screens 5440 compounds to identify chemical inhibitors effective against multiple coronaviruses, including SARS-CoV-2, finding several FDA-approved drugs with potential for repurposing.

The E3 ubiquitin ligase Mind bomb 1 enhances nuclear import of viral DNA by inactivating a virion linchpin protein that suppresses exposure of virion pathogen-associated molecular patterns

The paper shows that Mib1 ubiquitinates viral protein V to enable adenovirus DNA nuclear import, preventing innate immune activation.

Neuropilin-1 is a host factor for SARS-CoV-2 infection

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

Dynamic competition for hexon binding between core protein VII and lytic protein VI promotes adenovirus maturation and entry

This paper shows that competition between proteins VI and VII for hexon binding is essential for adenovirus maturation and endosome escape.

The FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of human adenoviruses

This paper shows that the FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of certain human adenoviruses but not non-lytic transmission.

High-content image-based drug screen identifies a clinical compound against cell transmission of adenovirus

The paper identifies Nelfinavir mesylate as an inhibitor of adenovirus multi-round plaque formation using an image-based high-throughput screening platform.

Cell-to-cell and genome-to-genome variability of Adenovirus transcription tuned by the cell cycle

This study investigates cell-to-cell and genome-to-genome variability in adenovirus transcription and replication, finding that host cell cycle state influences viral gene expression and genome activity.

Double-stranded RNA bending by AU-tract sequences

The paper identifies AU-tracts in dsRNA that cause structural bending through molecular dynamics simulations and AFM experiments.

Deep learning of virus infections reveals mechanics of lytic cells

The paper uses deep learning to predict lytic and nonlytic virus infections from imaging data, identifying key phenotypic differences 20 hours before lysis.

Label-free digital holo-tomographic microscopy reveals virus-induced cytopathic effects in live cells

This study introduces digital holo-tomographic microscopy to observe virus-induced cytopathic effects in live cells with minimal phototoxicity and reveals virus-specific changes.