A. Yakimovich

Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62

This study shows vaccinia virus evades xenophagy by phosphorylating and nuclear-targeting p62, preventing its role in pathogen degradation.

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

This study identifies ESCRT-III and VPS4 as essential for vaccinia virus packaging into multivesicular bodies, revealing an alternative pathway for virus egress.

The FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of human adenoviruses

This paper shows that the FDA-approved drug Nelfinavir inhibits lytic cell-free transmission of certain human adenoviruses but not non-lytic transmission.

High-content image-based drug screen identifies a clinical compound against cell transmission of adenovirus

The paper identifies Nelfinavir mesylate as an inhibitor of adenovirus multi-round plaque formation using an image-based high-throughput screening platform.

In vivo control of Toxoplasma gondii by zebrafish macrophages

This study uses a zebrafish model to show that macrophages control Toxoplasma gondii infection in vivo, with type II and III strains having higher infectious burdens than type I.

Deep learning of virus infections reveals mechanics of lytic cells

The paper uses deep learning to predict lytic and nonlytic virus infections from imaging data, identifying key phenotypic differences 20 hours before lysis.

An Artificial Intelligence Workflow for Defining Host-Pathogen Interactions

HRMAn is an open-source image analysis platform using machine learning to quantify host-pathogen interactions, demonstrating its ability to recognize and classify pathogen responses in Toxoplasma gondii and Salmonella typhimurium.

Label-free digital holo-tomographic microscopy reveals virus-induced cytopathic effects in live cells

This study introduces digital holo-tomographic microscopy to observe virus-induced cytopathic effects in live cells with minimal phototoxicity and reveals virus-specific changes.