M. Suomalainen

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

This study identifies alternative cell entry mechanisms for SARS-CoV-2 and other viruses, showing some rely on dynamin while others use actin-dependent pathways.

Arrayed multicycle drug screens identify broadly acting chemical inhibitors for repurposing against SARS CoV 2

The paper screens 5440 compounds to identify chemical inhibitors effective against multiple coronaviruses, including SARS-CoV-2, finding several FDA-approved drugs with potential for repurposing.

The E3 ubiquitin ligase Mind bomb 1 enhances nuclear import of viral DNA by inactivating a virion linchpin protein that suppresses exposure of virion pathogen-associated molecular patterns

The paper shows that Mib1 ubiquitinates viral protein V to enable adenovirus DNA nuclear import, preventing innate immune activation.

Dynamic competition for hexon binding between core protein VII and lytic protein VI promotes adenovirus maturation and entry

This paper shows that competition between proteins VI and VII for hexon binding is essential for adenovirus maturation and endosome escape.

Cell-to-cell and genome-to-genome variability of Adenovirus transcription tuned by the cell cycle

This study investigates cell-to-cell and genome-to-genome variability in adenovirus transcription and replication, finding that host cell cycle state influences viral gene expression and genome activity.

Double-stranded RNA bending by AU-tract sequences

The paper identifies AU-tracts in dsRNA that cause structural bending through molecular dynamics simulations and AFM experiments.