Pyrazinamide action is driven by the cell envelope stress response in Mycobacterium tuberculosis
J. M. Thiede, N. Dillon, M. D. Howe, S. J. Modlin, R. Aflakpui, S. Hoffner, F. Valafar, Y. Minato, A. D. Baughn
This study identifies that the cell envelope stress response drives pyrazinamide susceptibility in Mycobacterium tuberculosis, independent of pH, and shows that peptidoglycan synthesis inhibitors enhance its action.
bioRxiv · Feb 17, 2021 · PreprintMicrobiology