A. D. Baughn

α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

Unique genomic sequences in a novel Mycobacterium avium subsp. hominissuis lineage enable fine scale transmission route tracing during pig movement

This study identifies a novel Mycobacterium avium subsp. hominissuis lineage in pigs that enables transmission route tracing through unique genetic features.

Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan.

The paper analyzes 30 draft genomes of Mycobacterium avium subsp. hominissuis from Japanese pigs to characterize their genomic features and potential virulence.

Pyrazinamide action is driven by the cell envelope stress response in Mycobacterium tuberculosis

This study identifies that the cell envelope stress response drives pyrazinamide susceptibility in Mycobacterium tuberculosis, independent of pH, and shows that peptidoglycan synthesis inhibitors enhance its action.

Mechanism of selectivity reveals novel antifolate drug interactions

This study investigates PAS selectivity and finds it can antagonize sulfonamides and cause GI toxicity, suggesting caution in co-treatment for HIV-AIDS/M. tuberculosis co-infected individuals.

Genome-wide assessment of Mycobacterium tuberculosis conditionally essential metabolic pathways

This study identifies conditionally essential metabolic pathways in Mycobacterium tuberculosis using Tn-seq and in silico models, revealing gaps in current knowledge of its metabolic capabilities.

Methionine antagonizes para-aminosalicylic acid activity via affecting folate precursor biosynthesis pathway in Mycobacterium tuberculosis

This study identifies methionine's role in antagonizing PAS activity by affecting folate precursor biosynthesis in M. tuberculosis.