Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease
S. J. Borland, C. Facchi, J. Behnsen, A. Adamson, N. E. Humphreys, P. J. Withers, M. J. Sherratt, S. E. Francis, K. Brennan, N. Ashton, A. E. Canfield
This study shows that PKC loss increases uremia-induced arterial medial calcification in mice, suggesting PKC/TGF-β signaling as a therapeutic target.
bioRxiv · May 20, 2020 · PreprintCell Biology