Author

N. E. Humphreys

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

A. Adamson· 1 shared A. D. Adamson· 1 shared A. E. Canfield· 1 shared C. Facchi· 1 shared C. Lawrence· 1 shared D. Brough· 1 shared J. Behnsen· 1 shared J. Beswick· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Adamson

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2 papers

Recent·Most cited

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

J. P. Green, T. Swanton, L. V. Morris, L. Y. El-Sharkawy, J. Cook, S. Yu, J. Beswick, A. D. Adamson, N. E. Humphreys, R. Bryce, S. Freeman, C. Lawrence, D. Brough

This study identifies LRRC8A as a key regulator of hypotonicity-induced NLRP3 inflammasome activation, distinct from DAMP-induced activation.

bioRxiv · Jun 11, 2020Immunology

Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease

S. J. Borland, C. Facchi, J. Behnsen, A. Adamson, N. E. Humphreys, P. J. Withers, M. J. Sherratt, S. E. Francis, K. Brennan, N. Ashton, A. E. Canfield

This study shows that PKC loss increases uremia-induced arterial medial calcification in mice, suggesting PKC/TGF-β signaling as a therapeutic target.

bioRxiv · May 20, 2020 · PreprintCell Biology