A. Adamson

Proximity labelling and evolutionary evidence reveal insights into IL-1α nuclear networks and function

The paper investigates the nuclear role of pro-IL-1 and evolutionary changes in its NLS and HAT-binding domains using proximity labelling and mutation analysis.

Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.

This study identifies subtype-specific circadian clock dysregulation in breast cancer, linking it to EMT, invasiveness, and poorer prognosis.

Profile of the somatic mutational landscape in breast tumors from Hispanic/Latina women

This study analyzes the somatic mutational landscape of breast tumors in Hispanic/Latina women using whole-exome and RNA-seq, identifying common mutations and novel mutation signatures.

A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations

The paper develops a pipeline to identify BM-associated proteins, finds new regulators, and links BM genes to human disease.

Adipocyte REVERBα dictates adipose tissue expansion during obesity

This study shows adipocyte REVERBα regulates metabolic processes in white adipose tissue during obesity, preventing inflammation and fibrosis without affecting daily lipogenesis rhythms.

Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease

This study shows that PKC loss increases uremia-induced arterial medial calcification in mice, suggesting PKC/TGF-β signaling as a therapeutic target.

Circadian control of the secretory pathway is a central mechanism in tissue homeostasis

The paper identifies a circadian mechanism regulating collagen synthesis, assembly, and degradation to maintain tissue homeostasis in mice.