An in vitro tumorigenesis model based on live cell-generated oxygen and nutrient gradients
A. C. Gilmore, S. J. Flaherty, V. Somasundaram, D. A. Scheiblin, S. J. Lockett, D. A. Wink, W. F. Heinz
This paper introduces a 2D live-cell chamber to model the tumor microenvironment, showing that breast cancer cells and macrophages generate hypoxic and nutrient gradients and exhibit spatially varying phenotypes.
bioRxiv · Aug 24, 2020Cancer Biology