Author

W. F. Heinz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:spatial domain detection· 3 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. A. Wink· 4 shared S. J. Lockett· 4 shared A. L. Gonzalez· 3 shared A. L. Wink· 3 shared C. Rangel· 3 shared D. Butcher· 3 shared D. W. McVicar· 3 shared E. F. Edmondson· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

D. A. Wink

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Author profile →

4 papers

Recent·Most cited

Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients

L. A. Ridnourl, R. Y. Cheng, W. F. Heinz, M. Pore, A. L. Gonzalez, E. L. Femino, R. Moffat, A. L. Wink, F. Imtiaz, L. Coutinho, D. Butcher, E. F. Edmondson, C. Rangel, S. T. Wong, S. Lipkowitz, , D. A. Wink

The paper identifies spatial interactions between NOS2, COX2, and T-effector cells in ER- breast cancer, linking these patterns to poor patient outcomes and suggesting potential therapeutic strategies.

bioRxiv · Dec 21, 2023 · PreprintCancer Biology

NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER- Breast Cancer

L. A. Ridnourl, W. F. Heinz, R. Y. Cheng, A. L. Wink, N. Kedei, M. Pore, F. Imtiaz, E. L. Femino, A. L. Gonzalez, L. Coutinho, D. Butcher, E. F. Edmondson, C. Rangel, R. J. Kinders, S. Lipkowitz, , D. A. Wink

This study identifies NOS2 and COX2 as key spatial targets in ER- breast cancer that influence immune phenotypes and clinical outcomes through spatial analysis of tumor microenvironments.

bioRxiv · Dec 21, 2023 · PreprintCancer Biology

Interferon-gamma is Quintessential for NOS and COX Expression in ER- Breast Tumors that Lead to Poor Outcome

R. Y. Cheng, L. A. Ridnourl, A. L. Wink, A. L. Gonzalez, E. L. Femino, H. Rittscher, V. Somasundarum, W. F. Heinz, L. Coutinho, C. Rangel, E. f. Edmondson, D. Butcher, R. J. Kinders, X. Li, S. T. Wong, , D. A. Wink

The paper shows IFN-gamma induces NOS2 and COX2 in ER-breast tumors, linked to poor outcomes, through spatial analysis of tumor microenvironments.

bioRxiv · Apr 6, 2023Cancer Biology

An in vitro tumorigenesis model based on live cell-generated oxygen and nutrient gradients

A. C. Gilmore, S. J. Flaherty, V. Somasundaram, D. A. Scheiblin, S. J. Lockett, D. A. Wink, W. F. Heinz

This paper introduces a 2D live-cell chamber to model the tumor microenvironment, showing that breast cancer cells and macrophages generate hypoxic and nutrient gradients and exhibit spatially varying phenotypes.

bioRxiv · Aug 24, 2020Cancer Biology