Author

V. Somasundaram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

D. A. Scheiblin· 2 shared D. A. Wink· 2 shared S. J. Lockett· 2 shared A. C. Gilmore· 1 shared A. J. Walke· 1 shared A. Koren· 1 shared A. L. Wink· 1 shared A. Warner· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

D. A. Scheiblin

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Author profile →

3 papers

Recent·Most cited

NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8+ T Cell Spatial Orientation and Density

V. Somasundaram, L. A. Ridnour, R. Y. S. Cheng, A. J. Walke, N. Kedei, D. D. Bhattacharyya, A. L. Wink, E. F. Edmondson, D. Butcher, A. Warner, T. H. Dorsey, D. A. Scheiblin, W. Heinz, R. J. Bryant, R. Kinders, , D. A. Wink

This paper shows that blocking NOS2 and COX2 reduces TNBC tumor growth and improves CD8+ T cell infiltration and spatial distribution in tumors.

bioRxiv · Jun 3, 2022 · PreprintCancer Biology

An in vitro tumorigenesis model based on live cell-generated oxygen and nutrient gradients

A. C. Gilmore, S. J. Flaherty, V. Somasundaram, D. A. Scheiblin, S. J. Lockett, D. A. Wink, W. F. Heinz

This paper introduces a 2D live-cell chamber to model the tumor microenvironment, showing that breast cancer cells and macrophages generate hypoxic and nutrient gradients and exhibit spatially varying phenotypes.

bioRxiv · Aug 24, 2020Cancer Biology

Replication timing alterations in leukemia reflect stable clinically-relevant changes in genome architecture

J. C. Rivera-Mulia, T. Sasaki, C. Trevilla-Garcia, N. Nakamichi, D. J. H. F. Knapp, C. Hammond, B. Chang, J. W. Tyner, M. Devidas, J. Zimmerman, K. Klein, V. Somasundaram, B. Druker, T. Gruber, A. Koren, , D. M. Gilbert

The paper compares DNA replication timing profiles of BCP-ALL leukemic samples with normal B-lineage differentiation stages to identify clinically relevant features.

bioRxiv · Apr 11, 2019 · PreprintCancer Biology