Author

S. J. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Ciulli· 1 shared C. Whitworth· 1 shared K. Rumpel· 1 shared K. S. Graim· 1 shared M. Galant· 1 shared M. He· 1 shared M. J. Roy· 1 shared S. Ali· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Ciulli

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2 papers

Recent·Most cited

Peptide-based capture-and-release purification of extracellular vesicles and statistical algorithm enabled quality assessment

Z. F. Greenberg, S. Ali, T. D. Schmittgen, S. Han, S. J. Hughes, K. S. Graim, M. He

This paper introduces a peptide-based EV isolation method and a statistical algorithm to assess EV quality, showing improved identification of tumor markers in pancreatic cancer samples.

bioRxiv · Feb 6, 2024 · PreprintBioengineering

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

M. J. Roy, S. Winkler, S. J. Hughes, C. Whitworth, M. Galant, W. Farnaby, K. Rumpel, A. Ciulli

This paper develops an SPR-based assay to measure PROTAC ternary complex dissociation kinetics and shows that differences in off-rates correlate with target degradation efficiency.

bioRxiv · Feb 3, 2019Biochemistry