Author

K. Rumpel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Ciulli· 1 shared A. E. Gavard· 1 shared A. Meinhart· 1 shared C. Whitworth· 1 shared D. Kessler· 1 shared J. A. Newman· 1 shared J. Boettcher· 1 shared J. R. Engen· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperBiochemistry

A. Ciulli

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Author profile →

3 papers

Recent·Most cited

Crystal Structure of the Werner's Syndrome Helicase

J. A. Newman, A. E. Gavard, S. Lieb, M. C. Ravichandran, K. Hauer, P. Werni, L. Geist, J. Boettcher, J. R. Engen, K. Rumpel, M. Samwer, M. Petronczki, O. Gileadi

This study determines the crystal structure of the WRN helicase core and identifies structural features that may aid in designing inhibitors against WRN helicase.

bioRxiv · May 4, 2020 · PreprintBiochemistry

Native mass spectrometry can effectively predict PROTAC efficacy

R. Beveridge, D. Kessler, K. Rumpel, P. Ettmayer, A. Meinhart, T. Clausen

This study shows native mass spectrometry can detect PROTAC-mediated protein interactions and identify preferred E3-PROTAC-POI combinations in competition experiments.

bioRxiv · Nov 25, 2019Biochemistry

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

M. J. Roy, S. Winkler, S. J. Hughes, C. Whitworth, M. Galant, W. Farnaby, K. Rumpel, A. Ciulli

This paper develops an SPR-based assay to measure PROTAC ternary complex dissociation kinetics and shows that differences in off-rates correlate with target degradation efficiency.

bioRxiv · Feb 3, 2019Biochemistry