S. Winkler

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

This study shows that constitutive STING activation in mice causes SAVI, and TNF signaling mediates its pathogenesis, with TNFR1/2 inhibition improving disease symptoms.

Expanded olfactory system in fishes capable of terrestrial exploration

The paper examines the relationship between ecological traits and olfactory receptor gene expansions in ray-finned fishes, finding convergent increases in olfactory system size in amphibious species.

The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia

This study shows that inhibiting the NLRP3 inflammasome reduces AML cell proliferation by promoting eIF2 phosphorylation and cell cycle arrest.

Phylogenetic analysis of SARS-CoV-2 lineage development across the first and second waves in Eastern Germany, 2020

The paper analyzes SARS-CoV-2 lineage development in Eastern Germany during the first and second waves, identifying new variants introduced in 2020 as the main cause of the second wave.

Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy

This study shows that Flg-deficient mice do not develop spontaneous skin inflammation or atopy, but Flg deficiency may modulate dermatitis caused by other barrier defects.

Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma

This study shows that LamOVA, a hypoallergenic beta-glucan neoglycoconjugate, suppresses lung inflammation and reduces side effects in a mouse asthma model when delivered via laser-facilitated epicutaneous immunotherapy.

Multiple layers of phospho-regulation coordinate metabolism and the cell cycle in budding yeast

This study identifies cell cycle-dependent phosphorylation and dephosphorylation of metabolic enzymes in budding yeast, revealing mechanisms linking the cell cycle to metabolic regulation.

Evolved for success in novel environments: the round goby genome

The paper presents a long-read genome assembly of the round goby and identifies gene family expansions associated with its ecological success in novel environments.

SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate

This paper develops an SPR-based assay to measure PROTAC ternary complex dissociation kinetics and shows that differences in off-rates correlate with target degradation efficiency.