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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
V. Vetma, L. C. Perez, J. Elias, A. Stingu, A. Kombara, T. Gmaschitz, N. Braun, T. Ciftci, G. Dahmann, E. Diers, T. Gerstberger, P. Greb, G. Kidd, C. Kofink, I. Puoti, , M. Koegl
This study shows that the natural half-life of a target protein significantly affects degradation by degrader agents and highlights confounding factors in screening for protein degraders.
bioRxiv · Feb 19, 2024Cancer Biology
J. Popow, W. Farnaby, A. Gollner, C. Kofink, G. Fischer, M. Wurm, D. Zollman, A. Wijaya, N. Mischerikow, C. Hasenoehrl, P. Prokofeva, H. Arnhof, S. Arce-Solano, S. Bell, G. Boeck, , A. Ciulli
A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.
bioRxiv · Oct 24, 2023Pharmacology & Toxicology
M. J. Roy, S. Winkler, S. J. Hughes, C. Whitworth, M. Galant, W. Farnaby, K. Rumpel, A. Ciulli
This paper develops an SPR-based assay to measure PROTAC ternary complex dissociation kinetics and shows that differences in off-rates correlate with target degradation efficiency.
bioRxiv · Feb 3, 2019Biochemistry