Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies
S. J. Lehman, A. Meller, S. O. Solieva, J. M. Lotthammer, L. Greenberg, S. J. Langer, M. J. Greenberg, J. C. Tardiff, G. R. Bowman, L. A. Leinwand
This study shows that two point mutations at the same residue in beta-myosin heavy chain cause distinct cardiomyopathies through different molecular mechanisms.
bioRxiv · Jul 3, 2023 · PreprintBiophysics