Author

J. C. Tardiff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:microscopy & imaging analysis· 1 Approach:statistical model· 1

Frequent Co-Authors

A. M. Murphy· 1 shared A. Meller· 1 shared A. P. Baldo· 1 shared C. Gibson· 1 shared C. Vasquez· 1 shared G. R. Bowman· 1 shared J. Jimenez· 1 shared J. M. Lotthammer· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

A. M. Murphy

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2 papers

Recent·Most cited

The HCM-Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC-cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation

M. L. Lynn, J. Jimenez, R. L. Castillo, M. M. Klass, C. Vasquez, A. P. Baldo, C. Gibson, A. M. Murphy, J. C. Tardiff

This paper investigates how the HCM-linked mutation Arg92Leu in TNNT2 alters the cTnC-cTnI interface, impairing PKA access and causing early diastolic dysfunction.

bioRxiv · Jul 18, 2023 · PreprintBiophysics

Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies

S. J. Lehman, A. Meller, S. O. Solieva, J. M. Lotthammer, L. Greenberg, S. J. Langer, M. J. Greenberg, J. C. Tardiff, G. R. Bowman, L. A. Leinwand

This study shows that two point mutations at the same residue in beta-myosin heavy chain cause distinct cardiomyopathies through different molecular mechanisms.

bioRxiv · Jul 3, 2023 · PreprintBiophysics